Molecular Modeling of Acid Sensing Ion Channels
نویسندگان
چکیده
منابع مشابه
Acid-Sensing Ion Channels
Acetylcholine is a neurotransmitter synthesized from choline and acetyl coenzyme A. It is localized in large reticular formation neurons, and is the chemical mediator in the synapse of a motor endplate. The electrical signal of the motor nerve terminal causes release of many packets of acetylcholine. The packets are released into the synaptic cleft, where receptors in the postjunctional membran...
متن کاملAcid-sensing ion channels in gastrointestinal function
Gastric acid is of paramount importance for digestion and protection from pathogens but, at the same time, is a threat to the integrity of the mucosa in the upper gastrointestinal tract and may give rise to pain if inflammation or ulceration ensues. Luminal acidity in the colon is determined by lactate production and microbial transformation of carbohydrates to short chain fatty acids as well a...
متن کاملAcid-Sensing Ion Channels: Structure and Function
The ASIC channels constitute a subfamily within the larger ENaC superfamily. Despite the fact that the ASICs share only about 20-25% identity with the ENaC channels they display all the characteristics of the superfamily, which are, two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functional channel of the superfamily is composed of 4...
متن کاملAcid-Sensing Ion Channels and Pain
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provi...
متن کاملNeurosensory mechanotransduction through acid-sensing ion channels
Acid-sensing ion channels (ASICs) are voltage-insensitive cation channels responding to extracellular acidification. ASIC proteins have two transmembrane domains and a large extracellular domain. The molecular topology of ASICs is similar to that of the mechanosensory abnormality 4- or 10-proteins expressed in touch receptor neurons and involved in neurosensory mechanotransduction in nematodes....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.937.28